Functional trajectories during innate spinal cord repair

Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging adult neurogenesis hallmarks cellular regeneration during repair. However, the correlation between these regenerative processes remains to be elucidated. Whereas majority established metrics measure swim capacity, we hypothesize that gait quality is more directly related neurological health. Here, performed a longitudinal tracking study for 60 individual spanning 8 weeks regeneration. Multiple parameters as well axonal were integrated. We rostral compensation new metric highly correlates with recovery. Tensor component analysis data supports correspondence trajectories outcomes. Moreover, our studies predicted validated subset measured 1 2 post-injury sufficient predict outcomes animals at post-injury. Our findings generated comprehensive correlative database various outputs.